Childbearing, Child-Rearing, Cardiovascular Risk Factors, and Progression of Carotid Intima-Media Thickness: The Cardiovascular Risk in Young Finns Study
Identifieur interne : 007A00 ( Main/Exploration ); précédent : 007999; suivant : 007A01Childbearing, Child-Rearing, Cardiovascular Risk Factors, and Progression of Carotid Intima-Media Thickness: The Cardiovascular Risk in Young Finns Study
Auteurs : Michael R. Skilton [Australie] ; Fabrice Bonnet [France] ; Lisa M. Begg [Australie] ; Markus Juonala [Finlande] ; Mika K Hönen [Finlande] ; Terho Lehtim Ki [Finlande] ; Jorma S. A. Viikari [Finlande] ; Olli T. Raitakari [Finlande]Source :
- Stroke : (1970) [ 0039-2499 ] ; 2010.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Enfant.
English descriptors
- KwdEn :
Abstract
Background and Purpose-Parity is associated with the risk of clinical cardiovascular events and the severity of preclinical atherosclerosis in older subjects. We sought to determine whether childbearing is associated with concurrent changes in cardiovascular risk factors and the progression of carotid intima-media thickness. Methods-We examined the association between the number of children born during a 6-year period and concurrent changes in cardiovascular risk factors and progression of carotid intima-media thickness in men and women of reproductive age from the Cardiovascular Risk in Young Finns study. Complete data for parity and carotid intima-media thickness were available for 1786 subjects (1005 females, 781 males). Results-For females, childbirth during the 6-year follow-up was associated with concurrent reductions in high-density lipoprotein cholesterol (Ptrend<0.0001), apolipoprotein A-I (Ptrend<0.0001), and apolipoprotein B (Ptrend=0.01); a redistribution of adiposity to abdominal deposits; and increased progression of carotid intima-media thickness (7.5±3.2 μm/birth [mean±SEM], P=0.02). The association of childbirth with carotid intima-media thickness progression was not greatly modified by adjustment for concurrent changes in cardiovascular risk factors (fully adjusted: P=0.05). This association was significantly stronger in females than males (Pheterogeneity=0.001), who served as a control group exposed to the social and lifestyle influences of child-rearing but not the biological influences of childbearing. Conclusions-The progression of carotid atherosclerosis over a 6-year period is increased in females who gave birth during the same period, independent of traditional risk factors. Mechanisms that underlie this observation possibly include parity-induced changes in nontraditional risk factors or an acute influence of pregnancy itself.
Affiliations:
- Australie, Finlande, France
- Finlande occidentale, Région Bretagne, Victoria (État)
- Melbourne, Rennes, Turku
- Université de Turku
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Skilton</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Baker IDI Heart & Diabetes Institute</s1><s2>Melbourne</s2><s3>AUS</s3><sZ>1 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Bonnet, Fabrice" sort="Bonnet, Fabrice" uniqKey="Bonnet F" first="Fabrice" last="Bonnet">Fabrice Bonnet</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Department of Medicine Endocrinology Unit, CHU Rennes, Université Rennes 1</s1><s2>Rennes</s2><s3>FRA</s3><sZ>2 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Région Bretagne</region><region type="old region">Région Bretagne</region><settlement type="city">Rennes</settlement></placeName></affiliation></author><author><name sortKey="Begg, Lisa M" sort="Begg, Lisa M" uniqKey="Begg L" first="Lisa M." last="Begg">Lisa M. Begg</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Department of Obstetrics & Gynecology, Royal Women's Hospital</s1><s2>Melbourne</s2><s3>AUS</s3><sZ>3 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Juonala, Markus" sort="Juonala, Markus" uniqKey="Juonala M" first="Markus" last="Juonala">Markus Juonala</name><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Department of Medicine, University of Turku and Turku University Hospital</s1><s2>Turku</s2><s3>FIN</s3><sZ>4 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>Finlande</country><placeName><settlement type="city">Turku</settlement><region type="région" nuts="2">Finlande occidentale</region></placeName></affiliation><affiliation wicri:level="4"><inist:fA14 i1="05"><s1>Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku</s1><s2>Turku</s2><s3>FIN</s3><sZ>4 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Finlande</country><placeName><settlement type="city">Turku</settlement><region type="région" nuts="2">Finlande occidentale</region><settlement type="city">Turku</settlement></placeName><orgName type="university">Université de Turku</orgName></affiliation></author><author><name sortKey="K Honen, Mika" sort="K Honen, Mika" uniqKey="K Honen M" first="Mika" last="K Hönen">Mika K Hönen</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Department of Clinical Physiology, Tampere University, Hospital and University of Tampere</s1><s2>Tampere</s2><s3>FIN</s3><sZ>5 aut.</sZ></inist:fA14><country>Finlande</country><wicri:noRegion>Tampere</wicri:noRegion></affiliation></author><author><name sortKey="Lehtim Ki, Terho" sort="Lehtim Ki, Terho" uniqKey="Lehtim Ki T" first="Terho" last="Lehtim Ki">Terho Lehtim Ki</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Department of Clinical Chemistry, Tampere University Hospital and University of Tampere</s1><s2>Tampere</s2><s3>FIN</s3><sZ>6 aut.</sZ></inist:fA14><country>Finlande</country><wicri:noRegion>Tampere</wicri:noRegion></affiliation></author><author><name sortKey="Viikari, Jorma S A" sort="Viikari, Jorma S A" uniqKey="Viikari J" first="Jorma S. A." last="Viikari">Jorma S. A. Viikari</name><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Department of Medicine, University of Turku and Turku University Hospital</s1><s2>Turku</s2><s3>FIN</s3><sZ>4 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>Finlande</country><placeName><settlement type="city">Turku</settlement><region type="région" nuts="2">Finlande occidentale</region></placeName></affiliation></author><author><name sortKey="Raitakari, Olli T" sort="Raitakari, Olli T" uniqKey="Raitakari O" first="Olli T." last="Raitakari">Olli T. Raitakari</name><affiliation wicri:level="4"><inist:fA14 i1="05"><s1>Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku</s1><s2>Turku</s2><s3>FIN</s3><sZ>4 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Finlande</country><placeName><settlement type="city">Turku</settlement><region type="région" nuts="2">Finlande occidentale</region><settlement type="city">Turku</settlement></placeName><orgName type="university">Université de Turku</orgName></affiliation><affiliation wicri:level="4"><inist:fA14 i1="08"><s1>Department of Clinical Physiology, University of Turku</s1><s2>Turku</s2><s3>FIN</s3><sZ>8 aut.</sZ></inist:fA14><country>Finlande</country><placeName><settlement type="city">Turku</settlement><region type="région" nuts="2">Finlande occidentale</region><settlement type="city">Turku</settlement></placeName><orgName type="university">Université de Turku</orgName></affiliation></author></analytic><series><title level="j" type="main">Stroke : (1970)</title><title level="j" type="abbreviated">Stroke : (1970)</title><idno type="ISSN">0039-2499</idno><imprint><date when="2010">2010</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Stroke : (1970)</title><title level="j" type="abbreviated">Stroke : (1970)</title><idno type="ISSN">0039-2499</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Atherosclerosis</term><term>Cardiovascular disease</term><term>Carotid</term><term>Cerebrovascular disease</term><term>Child</term><term>Nervous system diseases</term><term>Parity</term><term>Risk factor</term><term>Stroke</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Pathologie de l'appareil circulatoire</term><term>Athérosclérose</term><term>Pathologie du système nerveux</term><term>Pathologie cérébrovasculaire</term><term>Accident cérébrovasculaire</term><term>Enfant</term><term>Facteur risque</term><term>Carotide</term><term>Parité</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Enfant</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Background and Purpose-Parity is associated with the risk of clinical cardiovascular events and the severity of preclinical atherosclerosis in older subjects. We sought to determine whether childbearing is associated with concurrent changes in cardiovascular risk factors and the progression of carotid intima-media thickness. Methods-We examined the association between the number of children born during a 6-year period and concurrent changes in cardiovascular risk factors and progression of carotid intima-media thickness in men and women of reproductive age from the Cardiovascular Risk in Young Finns study. Complete data for parity and carotid intima-media thickness were available for 1786 subjects (1005 females, 781 males). Results-For females, childbirth during the 6-year follow-up was associated with concurrent reductions in high-density lipoprotein cholesterol (P<sub>trend</sub><0.0001), apolipoprotein A-I (P<sub>trend</sub><0.0001), and apolipoprotein B (P<sub>trend</sub>=0.01); a redistribution of adiposity to abdominal deposits; and increased progression of carotid intima-media thickness (7.5±3.2 μm/birth [mean±SEM], P=0.02). The association of childbirth with carotid intima-media thickness progression was not greatly modified by adjustment for concurrent changes in cardiovascular risk factors (fully adjusted: P=0.05). This association was significantly stronger in females than males (P<sub>heterogeneity</sub>=0.001), who served as a control group exposed to the social and lifestyle influences of child-rearing but not the biological influences of childbearing. Conclusions-The progression of carotid atherosclerosis over a 6-year period is increased in females who gave birth during the same period, independent of traditional risk factors. Mechanisms that underlie this observation possibly include parity-induced changes in nontraditional risk factors or an acute influence of pregnancy itself.</div></front></TEI><affiliations><list><country><li>Australie</li><li>Finlande</li><li>France</li></country><region><li>Finlande occidentale</li><li>Région Bretagne</li><li>Victoria (État)</li></region><settlement><li>Melbourne</li><li>Rennes</li><li>Turku</li></settlement><orgName><li>Université de Turku</li></orgName></list><tree><country name="Australie"><region name="Victoria (État)"><name sortKey="Skilton, Michael R" sort="Skilton, Michael R" uniqKey="Skilton M" first="Michael R." last="Skilton">Michael R. Skilton</name></region><name sortKey="Begg, Lisa M" sort="Begg, Lisa M" uniqKey="Begg L" first="Lisa M." last="Begg">Lisa M. Begg</name></country><country name="France"><region name="Région Bretagne"><name sortKey="Bonnet, Fabrice" sort="Bonnet, Fabrice" uniqKey="Bonnet F" first="Fabrice" last="Bonnet">Fabrice Bonnet</name></region></country><country name="Finlande"><region name="Finlande occidentale"><name sortKey="Juonala, Markus" sort="Juonala, Markus" uniqKey="Juonala M" first="Markus" last="Juonala">Markus Juonala</name></region><name sortKey="Juonala, Markus" sort="Juonala, Markus" uniqKey="Juonala M" first="Markus" last="Juonala">Markus Juonala</name><name sortKey="K Honen, Mika" sort="K Honen, Mika" uniqKey="K Honen M" first="Mika" last="K Hönen">Mika K Hönen</name><name sortKey="Lehtim Ki, Terho" sort="Lehtim Ki, Terho" uniqKey="Lehtim Ki T" first="Terho" last="Lehtim Ki">Terho Lehtim Ki</name><name sortKey="Raitakari, Olli T" sort="Raitakari, Olli T" uniqKey="Raitakari O" first="Olli T." last="Raitakari">Olli T. Raitakari</name><name sortKey="Raitakari, Olli T" sort="Raitakari, Olli T" uniqKey="Raitakari O" first="Olli T." last="Raitakari">Olli T. Raitakari</name><name sortKey="Viikari, Jorma S A" sort="Viikari, Jorma S A" uniqKey="Viikari J" first="Jorma S. A." last="Viikari">Jorma S. A. Viikari</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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